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Detail OneSee The “Brain Drain.” Sleep is designed to clear the brain of the potential neurotoxic waste products that accumulate during our waking hours. This brain waste removal is driven by cerebrospinal fluid transport, the pathway known as the glymphatic system.1 Therefore, sleep is neuroprotective for the brain. During sleep, our brain is very busy; for example, the microglial cells help remove the toxic protein beta-amyloid while the astrocytes prune away unnecessary synapses and repair the brain’s neural wiring. However, the same process is activated when the body is deprived of sleep…BUT, instead of only attacking toxins, microglial cells and astrocytes begin attacking healthy, functioning tissues. The study: sleep may be a biomarker for Alzheimer's prediction. In this recent study (https://www.cell.com/current-biology/fulltext/S0960-9822(20)31171-4) from Berkley, the investigating team looked at the buildup of amyloid plaques on positron emission tomography (PET) scans and correlated the changes with the quality of people’s sleep. Amyloid-β (Aβ) is a metabolic by-product whose aggregation into amyloid plaques is implicated in neurodegenerative processes. Study participants who started out experiencing more fragmented sleep and less non-rapid eye movement (non-REM), slow-wave sleep were most likely to show an increase in beta-amyloid over the course of the study. The implication is that sleep may be an indicator of disease and further research is needed to determine if sleep may also “represent a possible preventative and therapeutic target in modulating risk for AD and/or delaying the onset of AD symptoms.”2 Between 25 and 60% of patients with AD present with dysfunctional sleep, but the association between AD and sleep is bidirectional: not only does dysfunctional sleep contribute to the AD phenotype, but Aβ deposition itself leads to sleep disturbances. My previous blog talks about the frequency of sleep disordered breathing (SDB) in AD: https://www.suzannegazdamd.com/blog/sleep-and-brain-health-can-sleep-disordered-breathing-contribute-to-ad Most of us recognize that sleep is critical to our health and wellbeing as well as our productivity levels - and the influences of poor quality sleep as a societal problem, from educational success to things like safety - are truly concerning from so many perspectives. For some tips on how to sleep better, you’ll find some of our recommendations at: https://www.suzannegazdamd.com/blog/a-well-spent-day-brings-happy-sleep-leonardo-da-vinci https://www.suzannegazdamd.com/blog/your-brains-wellbeing-starts-with-sleeping-well Remember that we learn when we dream as our vivid dreams shape our memories – so we wish you sweet dreams every night and a reminder not to wait to talk to your health care provider if sleeping poorly becomes a regular occurrence! In health and healing, Dr. Suzanne Gazda References: 1 Haugland, N.L., Pavan, C., Nedergaard, N. Cleaning the sleeping brain – the potential restorative function of the glymphatic system. Current Opinion in Physiology. (June 2020) https://www.sciencedirect.com/science/article/pii/S2468867319301609 https://doi.org/10.1016/j.cophys.2019.10.020 2 Winer, J.R., Mander, B.A., Kumar, S. et al. Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years. Published online Current Biology. September 3, 2020. https://doi.org/10.1016/j.cub.2020.08.017 |
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